The 2013 Stem Cells Discussion Forum: Working Towards Clinical Application

London, London
Thursday, 06 June 2013

The venue for this event is The Royal College of Pathologists

 2 Carlton House Terrace is the home of the Royal College of Pathologists, a professional membership organisation, concerned with all matters relating to the science and practice of pathology.

Carlton House Terrace was constructed largely between 1826  and 1829 and it remains the property of the Queen.   Its balconies overlook the Mall in central London where Buckingham Palace stands.

This is a Euroscicon Small Conference,  an outline of the day can be found at 
www.euroscicon.com/EurosciconMeetingStructure.pdf

The 2013 Stem Cells Discussion Forum: Working Towards Clinical Application
Thursday, 06 June 2013 09:00 - 17:00

The Royal College of Pathologists
2 Carlton House Terrace
London
London
SW1Y 5AF
United Kingdom

Map and Directions


This event is discussion forum, focused on clinical applications of stem cell therapy. The aim is to offer participants a chance to explore aspects with the experts during round table and one-to one discussions.

 

Meeting Chair: Dr Glyn Stacey, UK Stem Cell Bank, Division of Cell Biology and Imaging.

 

This event  has CPD accreditation and is part of the 2013 Euroscicon Stem Cell Trilogy.  

To find out more see www.stemcells2013.com

9:00 – 9:45          Registration

 

9:45 – 10:00        Introduction by the ChairDr Glyn Stacey, UK Stem Cell Bank, Div of Cell Biology and Imaging, NIBSC, MHPRA. 

 

10:00 – 10:30       First-in-Man trials of Stem Cells as Medicines – from single cells to 3-D constructs

Dr Mark Lowdell, University College London, UK

 

10:30 – 11:00     Biologic Augmentation of Rotator Cuff Repairs

Dr. James Hoffman, Coordinated Health, USA

Recurrent rotator cuff tears are a well documented problem.  Following surgical correction, healing of the rotator cuff is impeded by muscle atrophy, fat infiltration, devascularization, and scar tissue formation.  The structural integrity of the tendon is weakened, increasing the susceptibility to retear.  Consequently, biologic adjuvants and mechanical reinforcements have been suggested as a means of recreating a biomechanically equivalent layer of connective tissue.  Within, we present our initial clinical and histological findings evaluating the efficacy of a rotator cuff repair performed with platelet-rich plasma, a dermal allograft, and mesenchymal stem cells.

11:00 – 11:30       Generating hESCs for Clinical Application: The Challenges for Academics.

Dr Zoe Hewitt, Centre for Stem Cell Biology, The University of Sheffield

As momentum in the field of human embryonic stem cell (hESC) based therapies grows, researchers face the challenge of developing raw materials from which these therapies can be developed which are suitable for clinical application.  Consequently, there has been significant emphasis placed on deriving new hESC lines using good manufacturing practices (GMPs) to provide standard mechanisms for assessing reliability and reproducibility of these raw materials.  If GMP standards are to be met, the derivation process, which involves a range of procedures and mechanisms some of which are not yet fully understood, must be validated and implemented in a framework of strict quality management. 

11:30 – 12:00       Speakers’ photo then mid-morning break, poster sessions and trade show

Please try to visit all the exhibition stands during your day at this event.  Not only do our sponsors enable Euroscicon to keep the registration fees competitive, but they are also here specifically to talk to you

 

12:00 – 12:30       A risk based, unit operation approach to manufacturing process science for cell based therapies

Dr Robert Thomas, Loughborough University, UK

The EPSRC Centre for Innovative Manufacturing in Regenerative Medicine is developing manufacturing science for industrial production of advanced therapies. Key goals are reduction of risk and cost in translating development therapies to commercially viable products. Important steps include early process analysis, consideration of constituent units of operation, and risk assessment in the context of industrial operating restrictions and logistics. Key challenges such as identifying units of operation, required measurement system performance and frequency for process control, and application of engineering design for optimization, risk reduction, and decision making, will be discussed with examples from both academic and commercial development programs.

 

12:30 – 13:00       Stem cell treatment for multiple sclerosis

Professor Neil Scolding, Burden Professor of Clinical Neurosciences, University of Bristol, UK

Multiple sclerosis (MS) is a major cause of disability, particularly affecting young adults, in which patches of tissue damage occur throughout the brain and spinal cord. Recent advances in our understanding of how MS progresses have radically altered the way we think about cell therapy for this disease. The many and varied reparative properties of bone marrow derived stem cells may offer new and attractive possibilities for developing cell-based treatments for MS, with significant and positive implications also for other common neurodegenerative conditions.

 

13:00 – 14:00     Lunch,  poster sessions and trade show Please try to visit all the exhibition stands during your day at this event.  Not only do our sponsors enable Euroscicon to keep the registration fees competitive, but they are also here specifically to talk to you

 

Oral Presentations

14:00 – 14:15      HUMAN FETAL DOPAMINERGIC PRECURSOR CELL TRANSPLANTATION: LIF-NANOTHERAPY TO PROMOTE (i) IMMUNE TOLERANCE, AND (ii) GRAFT SURVIVAL.

Metcalfe Su M. Brain Repair Centre, Addenbrooke’s Hospital, Cambridge, CB2 0PQ, UK.

 

14:15 – 14:30       IMMUNOLOGICAL EFFECTS OF MESENCHYMAL STROMAL CELLS ON T CELL LINES FROM

CROHN’S DISEASE PATIENTS

R. Ciccocioppo, Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Piazzale Golgi, 19; 27100 Pavia; Italy

 

 

14:30 – 16:00       Round Table Discussions
Table 1: Mark Lowdell

Table 2: Professor Neil Scolding

Table 3: Robert Thomas

Table 4: Zoe Hewitt

Table 5: James Hoffman

16: 00 - 16:30      Question and Answer Session

Delegates will be asked to submit questions to a panel of experts.  Questions can be submitted before the event or on the day

 

16:30 – 17:00       Chairman’s summing up


About the Chair

Glyn Stacey, Head of the Division of Cell Biology and Imaging at NIBSC and Director for the UK Stem Cell Bank. 

His scientific background has been in microbiology and cancer research. From 1989-1998 he worked at Porton Down, UK, where he  developed cell banking procedures and the development of cells for manufacture of medical products and cell-based diagnostic  assays. At NIBSC he has developed a broad remit relating to the quality and safety of new biological medicines and therapies based  on the use of human and animal cells. He has also acted as an advisor to the UK Department of Health and the World Health  Organization. He coordinates the International Stem Cell Banking Initiative funded by a consortium of funding agencies from 20  countries. He has recently overseen the establishment of a new and expanded GMP facility for banking stem cell lines. He has  published numerous scientific papers and books on cell banking and quality control.

About the Speakers

Neil Scolding trained in neurology in Cardiff, Cambridge and London (National Hospital for Neurological Diseases), before being appointed foundation Burden Professor of Clinical Neurosciences at the University of Bristol and Frenchay Hospital. His main clinical research interests lie in multiple sclerosis and other inflammatory neurological diseases, and the biology and clinical development of stem cell therapies for MS and other neurodegenerative conditions. He has published four textbooks and some 150  research papers; is currently a Guarantor of the journal Brain; and is a member of the editorial board of various other journals, of the national bioethics committee ESBAC, and of the Association of British Neurologists Council.

 

Following Zoe Hewitt ‘s PhD at the Roslin Insitute in Edinburgh, where she studied the “elimination of undifferentiated human embryonic stem cells in vitro” as a method to address the associated risk of tumorgenicity from the accidental transplantation of undifferentiated hESCs within a therapeutic graft, Zoe moved to the Stem Cell Derivation Facility (SCDF) at the Centre for Stem Cell Biology, University of Sheffield to take up a role as Quality Manager.   Since 2006 she has been responsible for commissioning and managing a Clean Room Facility for the production of clincal grade human embryonic stem cells with a goal of making these available for use in future therapeutics.

Rob Thomas is a Senior Lecturer and EPSRC Bio-manufacturing Fellowship holder at Loughborough University. He is a leading member of the bio-manufacturing research team working to develop the process science and the manufacturing capability for cell based regenerative medicine therapies, with a particular focus on haematopoietic lineage based processes. He is currently associate director of the EPSRC Centre for Innovative Manufacturing in Regenerative Medicine led from the Centre for Biological Engineering at Loughborough University.

Keywords:   Clinical Trial Partnerships, stem cells, banking,manufacturing,scale-up,GMP, regenerative,IPS, ATMPs, somatic, stem cells, constructs, human embryonic stem cells, clinical grade, cGMP, macular degeneration, retinal pigment epithelium, RPE, AMD, multiple sclerosis, neurodegeneration,cell therapy, clinician-scientist, stem cell research, translation, career path, Stem Cells, Embryonic, clinical application,  Manufacture, Cell Therapies, Process

 

Event Web Site: www.regonline.co.uk/stem2013  

 

 

Contact Details

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