This is a Euroscicon Small Conference, an outline of the day can be found at
This meeting will present and discuss current research into cell cycle regulation including new approaches available to study this regulation.
This event is part of the 2013 Flow Cytometry Forum – www.FlowCytometry2013.com This event has CPD accreditation.
Meeting Chair: Dr Michael G Ormerod, Consultant, UK
The Deadline for abstract submissions for oral presentation has now passed. Abstracts for poster presentation only can be submitted up to two weeks before the event. There will be a best poster prize.
You can download the instructions for authors at
Who Should Attend
Flow cytometry specialists
Biotech and Pharma Industry: CEOs, Chief Scientists, Group Heads, Senior and Junior Scientists, Research Managers
Academic and Research Institutes: Group and Lab Heads, Postdoctoral Scientists and Research Students
Talk times include 5 – 10 minutes for questions
9:00 – 9:45 Registration
9:45 – 10:00 Introduction by the Chair: Dr Michael G Ormerod, Consultant, UK
10:00 – 10:40 Nuclear Envelope Influences on the Cell Cycle
Dr. Eric C. Schirmer, University of Edinburgh, Scotland
The nuclear envelope (NE) is a double membrane system surrounding the nucleus that can influence the cell cycle in several different ways. Failure to properly disassemble the NE in prophase can block mitosis or result in lagging chromosomes. Moreover, many NE proteins appear to have separate roles in mitosis once disassembled. Finally, several NE proteins can impact on checkpoints and pathways that allow cell cycle progression and some can directly bind the master cell cycle regulator pRb to stabilize and sequester it. This latter can result in these NE proteins having both positive and negative effects depending on associated factors.
10:40 – 11:20 Sensing oxygen stress in the cell
Dr. Sonia Rocha, FSB, Centre for Gene Regulation and Expression College of Life Sciences, University of Dundee, Scotland
Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions. HIF-α subunit quantities and their associated activity are regulated in a post-translational manner, through the concerted action of a class of enzymes called Prolyl Hydroxylases and Factor Inhibiting HIF respectively. These enzymes are the cell molecular oxygen sensors. We have been investigating other molecular processes altered by oxygen these include global chromatin structure and the cell cycle. We shall be presenting our latest results concerning the molecular mechanisms connecting oxygen sensing to some of these important cellular processes.
11:20 – 12:00 Speakers’ photo then mid-morning break and poster exhibition and trade show
12:00 – 12:40 The role of the transcriptional networks in controlling cell cycle progression and genome stability
Robert de Bruin, MRC Laboratory for Molecular Cell Biology University College London
The eukaryotic cell cycle is controlled by a regulatory network whose general features are conserved from yeast to humans. Our work investigates the G1/S transcriptional network involved in two crucial aspects of cell cycle regulation, cell division cycle control and maintenance of genome stability. Our recent work reveals how cells cope with the deregulated activities of G1/S transcription factors, which creates specific cellular requirements for replication control and genome protection mechanisms. Since deregulated G1/S transcription is found in nearly all types of cancers our future work will explore how these vulnerabilities could be exploited to identify potential anti-cancer drug targets.
12:40 – 14:00 Lunch, poster exhibition and trade show
14:00 – 15:00 Question and Answer Session
15: 00 – 15:30 Afternoon Tea, last poster session and trade show
15:30 – 16:10 Oxidative stress and the regulation of the cell cycle
Professor Brian Morgan, Personal Chair of Yeast Molecular Biology, Institute for Cell and Molecular Biosciences
Newcastle University, UK
Oxidative stress caused by high levels of reactive oxygen species (ROS) is intimately linked with common diseases such as cancer. However, ROS are also beneficial with low levels utilised as signalling molecules. Thus, to develop effective clinical strategies to target the “bad” health consequences of ROS it is vital to understand how cells respond to different levels of ROS. For example, the cell cycle is inhibited by oxidative stress to prevent damage/allow repair. We are using yeast as a model to investigate cellular oxidative stress responses and I will describe a novel regulatory mechanism important for cell cycle progression.
16:10 – 16:50 p53, the cell cycle, and opportunities for clinical exploitation
Dr David W Meek, Jacqui Wood Cancer Centre/CRC, University of Dundee, Scotland
The p53 tumour suppressor plays a fundamental role in inhibiting or delaying the development of most types of cancer. p53 is a transcription factor which controls cell cycle checkpoints and apoptosis by orchestrating changes in gene expression in a stimulus-dependent manner. I will discuss recent developments in our understanding of how p53 controls the crucial cell cycle-regulatory enzyme, PLK1 (polo-like kinase-1) and the significance of this model for breast cancer development and treatment. I will also present our progress in understanding how MAGE-A proteins (Melanoma AntiGEns) block p53 activity and discuss novel approaches towards inhibiting these proteins therapeutically.
16:50 – 17:00 Chairman’s summing up
Keywords: Flow Cytometric & Image Analysis, Necrobiology, Apoptosis, Flow cytometry, apoptosis, Image Stream, T cells, Immunosenescence, Wnt, colorectal cancer, GMP-compliant, cytotoxicity Humira, ADCC, CDC, Cell death, proliferation dyes, cell imaging, cell morphology, Flow cytometry, nuclear envelope, NET, lamin, cell cycle, mitosis, Hypoxia, HIF, PHD, G1-to-S transition, G1/S transcription, Replication checkpoint, Genome stability, p53, cell cycle, checkpoints, tumour antigens, Cell cycle regulation, oxidative stress, reactive oxygen species, Saccharomyces cerevisiae
Registration Website: http://www.regonline.co.uk/cellcycle2013
Phone: 07507 799380
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An event from European Scientific Conferences - Euroscicon "Specialising in communicating cutting edge technology & methodology in the Life Sciences"
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Company number: 4326921, Trading Address: Euroscicon Ltd, Highstone House, 165 High Street, Barnet, Herts. EN5 5SU, UK. Registered Office: 47 High Street, Barnet, Herts, EN5 5UW, UK