This is a Euroscicon Small Conference, an outline of the day can be found at
This event will be held at The O2, a large entertainment district on the Greenwich peninsula in South East London, England.
Use of Kinetic Isotope Effect to Mitigate Age-related Oxidative Stress Diseases
Dr Mikhail Shchepinov, CSO, Retrotope, Inc, USA
Key oxidation prone positions within biomolecules can be reinforced with deuterium to make them more resistant to oxidative stress courtesy of the isotope effect. Use of this approach in mitigation of age-related diseases will be discussed.
Tenocyte metabolism in ageing and estrogen deficiency
Dr. Francesca Veronesi, Biotechnologist researcher, Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy
The study evaluated in vitro proliferation, metabolism and micro-wound healing of tenocytes isolated from the Achilles tendons of ovariectomised (OVX), middle-aged (OLD) and young (YOUNG) rats. OLD and OVX showed a lower proliferation, collagen I, aggrecan, elastin and nitric oxide production than YOUNG and fibronectin and elastin were lower in OVX than YOUNG and OLD. Vascular endothelial growth factor, collagen III and metalloproteinases-13 increased in OVX than in YOUNG and OLD. A lower healing rate was observed in OVX than OLD and YOUNG. Results highlighted how aging and more estrogen deficiency negatively affect tendon metabolism and healing.
Stress signalling pathways as targets for intervention in the premature ageing Werner Syndrome
Professor D Kipling, Cardiff University, School of Medicine, UK
Werner syndrome (WS, or adult progeria) is a rare human genetic disease associated with accelerated ageing. Cells from WS individuals undergo premature senescence in culture, a phenomenon long suggested to underpin the clinical symptoms. We have shown that small-molecule inhibition of the p38/MK2 stress signalling pathway can prevent the accelerated senescence of WS cells in culture. We will discuss how such inhibitors, many of which are in advanced clinical trials for inflammatory disease, may provide a route to therapeutic intervention in WS. They may also have potentially beneficial anti-ageing effects in normal individuals, via modulation of the senescence-associated secretory phenotype.
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An event from European Scientific Conferences - Euroscicon "Specialising in communicating cutting edge technology & methodology in the Life Sciences"
EuroSciCon Ltd. Registered in England and Wales,
Company number: 4326921, Trading Address: Euroscicon Ltd, Highstone House, 165 High Street, Barnet, Herts. EN5 5SU, UK. Registered Office: 47 High Street, Barnet, Herts, EN5 5UW, UK